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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Fernando Valenzuela* | 503 | 1984 | |
| 2 | Roger Clemens# | 417 | 1984 | |
| 3 | Bruce Berenyi | 370 | 1984 | |
| 4 | Nolan Ryan | 340 | 1984 | |
| 4 | Dave Stieb | 340 | 1984 | |
| 6 | Jack Morris | 330 | 1984 | |
| 7 | Mike Krukow | 310 | 1984 | |
| 8 | Len Barker | 309 | 1984 | |
| 9 | Pascual Perez | 306 | 1984 | |
| 9 | Jose DeLeon | 306 | 1984 | |
| 11 | Rick Rhoden | 303 | 1984 | |
| 12 | Mario Soto | 300 | 1984 | |
| 13 | Don Robinson | 299 | 1984 | |
| 14 | Lefty Grove# | 290 | 1993 | |
| 15 | Gus Krock | 289 | 1984 | |
| 16 | Lefty Grove# | 285 | 1987 | |
| 16 | Marty Bystrom | 285 | 1984 | |
| 18 | John Tudor | 284 | 1984 | |
| 19 | Mario Soto | 281 | 1982 | |
| 20 | Bob Welch | 279 | 1984 | |
| 21 | Rick Sutcliffe | 278 | 1984 | |
| 22 | Dave LaPoint | 272 | 1984 | |
| 23 | Charlie Lea | 270 | 1984 | |
| 23 | Christy Mathewson# | 270 | 1998 | |
| 25 | Lefty Grove# | 268 | 1989 | |
| 26 | Larry McWilliams | 267 | 1984 | |
| 27 | Christy Mathewson# | 266 | 1996 | |
| 28 | Lefty Grove# | 262 | 1992 | |
| 29 | Mike Boddicker | 261 | 1984 | |
| 30 | Steve Carlton | 256 | 1982 | |
| 31 | Fernando Valenzuela* | 255 | 1982 | |
| 32 | Yu Darvish# | 252 | 1998 | |
| 33 | Fernando Valenzuela* | 247 | 1983 | |
| 33 | Jim Beattie | 247 | 1984 | |
| 35 | Bill Wise# | 246 | 1992 | |
| 36 | Herb Score# | 245 | 1955 | |
| 36 | Christy Mathewson# | 245 | 1997 | |
| 38 | Bert Inks# | 244 | 1998 | |
| 38 | Tommy Bond# | 244 | 1995 | |
| 40 | Bob Ojeda | 243 | 1984 | |
| 40 | John Denny | 243 | 1984 | |
| 42 | Van Mungo# | 241 | 1994 | |
| 43 | Kevin Appier# | 237 | 1992 | |
| 44 | Lefty Grove# | 234 | 1991 | |
| 44 | Lefty Grove# | 234 | 1990 | |
| 46 | Nolan Ryan | 233 | 1980 | |
| 47 | Steve Carlton | 232 | 1984 | |
| 48 | Lefty Grove# | 224 | 1994 | |
| 49 | Roger Clemens# | 223 | 1986 | |
| 49 | Bert Inks# | 223 | 1997 | |
| 51 | Bob Knepper | 222 | 1984 | |
| 52 | Scott Sanderson | 221 | 1984 | |
| 52 | Ron Guidry | 221 | 1984 | |
| 52 | Roger Clemens# | 221 | 1992 | |
| 55 | Fernando Valenzuela* | 220 | 1986 | |
| 56 | Mario Soto | 218 | 1981 | |
| 57 | Roger Clemens# | 217 | 1997 | |
| 57 | Frank Tanana | 217 | 1984 | |
| 59 | Jim Bunning# | 216 | 1998 | |
| 60 | Ed Whitson | 215 | 1984 | |
| 61 | Britt Burns | 213 | 1984 | |
| 62 | Lefty Grove# | 210 | 1988 | |
| 62 | Roger Clemens# | 210 | 1987 | |
| 64 | Jack McDowell | 209 | 1986 | |
| 65 | Mario Soto | 208 | 1983 | |
| 65 | Felix Hernandez# | 208 | 1997 | |
| 65 | Clayton Kershaw# | 208 | 1997 | |
| 65 | Fernando Valenzuela* | 208 | 1981 | |
| 69 | Steve Carlton | 207 | 1980 | |
| 70 | Felix Hernandez# | 206 | 1998 | |
| 71 | Dave Righetti# | 204 | 1992 | |
| 72 | Bert Blyleven | 203 | 1980 | |
| 73 | Ernie Broglio# | 202 | 1992 | |
| 74 | Tim Lollar | 201 | 1984 | |
| 75 | Harry C. Harper# | 200 | 1998 | |
| 75 | Ben Sheets# | 200 | 1992 | |
| 77 | Van Mungo# | 199 | 1995 | |
| 78 | Hal Newhouser# | 198 | 1999 | |
| 78 | Fernando Valenzuela* | 198 | 1987 | |
| 78 | Clayton Kershaw# | 198 | 1998 | |
| 78 | J R Richard | 198 | 1984 | |
| 78 | Nolan Ryan | 198 | 1983 | |
| 78 | LaMarr Hoyt | 198 | 1984 | |
| 84 | Patrick Corbin | 192 | 1984 | |
| 84 | Curry Foley# | 192 | 1994 | |
| 86 | John Candelaria | 190 | 1984 | |
| 86 | Bill Gullickson | 190 | 1984 | |
| 86 | J R Richard | 190 | 1980 | |
| 89 | Paul Derringer# | 189 | 1998 | |
| 89 | Bill Walker# | 189 | 1997 | |
| 89 | Nolan Ryan | 189 | 1982 | |
| 92 | Bruce Berenyi | 188 | 1981 | |
| 92 | Nolan Ryan | 188 | 1981 | |
| 92 | Jim Bunning# | 188 | 1999 | |
| 92 | Bill Gullickson | 188 | 1981 | |
| 96 | Mike Scott | 186 | 1986 | |
| 97 | Al Orth# | 185 | 1997 | |
| 98 | Shane Rawley | 184 | 1984 | |
| 98 | Steven Matz | 184 | 1984 | |
| 100 | Floyd Bannister | 183 | 1983 |
