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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Roger Clemens# | 258 | 1982-1999 | |
| 2 | Lefty Grove# | 211 | 1986-1999 | |
| 3 | Fernando Valenzuela* | 208 | 1980-1996 | |
| 4 | Patrick Corbin | 201 | 1982-1997 | |
| 5 | Jack Morris | 175 | 1980-1992 | |
| 6 | Early Wynn# | 171 | 1939-1999 | |
| 7 | Rick Rhoden | 165 | 1980-1990 | |
| 8 | John Denny | 159 | 1980-1992 | |
| 9 | Bob Welch | 157 | 1980-1991 | |
| 10 | Ben Sheets# | 152 | 1987-1999 | |
| 11 | Jose DeLeon | 150 | 1984-1997 | |
| 12 | Charlie Leibrandt | 149 | 1981-1994 | |
| 13 | John Tudor | 148 | 1980-1994 | |
| 14 | Danny Darwin | 146 | 1980-1995 | |
| 14 | Masahiro Tanaka | 146 | 1984-1996 | |
| 16 | Dave Stieb | 140 | 1981-1992 | |
| 17 | Frank Tanana | 139 | 1980-1990 | |
| 18 | Bob Ojeda | 137 | 1980-1993 | |
| 19 | Scott Sanderson | 135 | 1980-1993 | |
| 20 | Kevin Appier# | 134 | 1988-1999 | |
| 20 | Jack McDowell | 134 | 1983-1994 | |
| 20 | Van Mungo# | 134 | 1987-1999 | |
| 23 | Pascual Perez | 131 | 1981-1992 | |
| 24 | Ed Brandt# | 129 | 1986-1999 | |
| 24 | Bruce Hurst | 129 | 1982-1994 | |
| 26 | Mike Boddicker | 128 | 1981-1993 | |
| 27 | John Candelaria | 125 | 1980-1991 | |
| 28 | Vinegar Bend Mizell# | 123 | 1988-1999 | |
| 29 | Don Robinson | 121 | 1980-1994 | |
| 30 | Nolan Ryan | 117 | 1980-1988 | |
| 31 | Bill Gullickson | 115 | 1980-1991 | |
| 32 | Moose Haas | 110 | 1981-1989 | |
| 32 | Arlie Pond# | 110 | 1988-1999 | |
| 32 | Mike Scott | 110 | 1980-1991 | |
| 35 | Claude Osteen# | 109 | 1988-1999 | |
| 36 | Rick Sutcliffe | 106 | 1980-1990 | |
| 37 | Dan Haren# | 105 | 1991-1999 | |
| 37 | Kenta Maeda | 105 | 1986-1995 | |
| 37 | Al Orth# | 105 | 1991-1999 | |
| 40 | Jordan M Zimmermann# | 104 | 1989-1999 | |
| 41 | Ed Whitson | 103 | 1980-1991 | |
| 42 | Jeff Weaver# | 98 | 1986-1999 | |
| 43 | Ron Guidry | 97 | 1980-1990 | |
| 43 | Scott Kazmir# | 97 | 1987-1999 | |
| 45 | Steve Carlton | 96 | 1980-1987 | |
| 45 | Dave LaPoint | 96 | 1981-1991 | |
| 47 | Bob Knepper | 95 | 1980-1989 | |
| 48 | Chuck Stobbs | 93 | 1947-1991 | |
| 48 | Happy Townsend# | 93 | 1984-1999 | |
| 50 | Scott T Baker | 92 | 1982-1991 | |
| 51 | Jerry Reuss | 90 | 1980-1987 | |
| 51 | Carlos Zambrano# | 90 | 1988-1999 | |
| 53 | Mike Krukow | 89 | 1980-1988 | |
| 54 | Pedro Ramos# | 88 | 1955-1996 | |
| 55 | Shane Rawley | 87 | 1980-1992 | |
| 56 | Len Barker | 85 | 1980-1985 | |
| 57 | Heinie Berger# | 84 | 1992-1999 | |
| 57 | Johnny Lush | 84 | 1987-1996 | |
| 57 | Al Mamaux# | 84 | 1994-1999 | |
| 57 | Mario Soto | 84 | 1980-1987 | |
| 61 | Ernie Broglio# | 83 | 1991-1999 | |
| 62 | Frank Browning# | 82 | 1989-1999 | |
| 63 | David Palmer | 80 | 1980-1991 | |
| 63 | Dave Righetti# | 80 | 1991-1999 | |
| 65 | LaMarr Hoyt | 79 | 1980-1991 | |
| 65 | J R Richard | 79 | 1980-1985 | |
| 67 | Billy Loes | 78 | 1984-1999 | |
| 68 | Floyd Bannister | 77 | 1980-1989 | |
| 68 | Johnny Cueto# | 77 | 1992-1999 | |
| 68 | Dennis Eckersley | 77 | 1980-1995 | |
| 71 | David Clyde# | 76 | 1986-1999 | |
| 71 | Aaron Harang# | 76 | 1989-1998 | |
| 73 | Bruce Berenyi | 75 | 1981-1986 | |
| 74 | Steven Matz | 73 | 1983-1993 | |
| 75 | Tim Leary# | 72 | 1991-1999 | |
| 76 | Freddie Fitzsimmons# | 70 | 1980-1999 | |
| 77 | Jim Abbott# | 69 | 1990-1997 | |
| 77 | Jeff C D'Amico | 69 | 1983-1993 | |
| 77 | Matt Harrison | 69 | 1984-1990 | |
| 77 | Dennis Martinez | 69 | 1980-1990 | |
| 81 | Britt Burns | 68 | 1980-1996 | |
| 81 | Christy Mathewson# | 68 | 1994-1999 | |
| 83 | Marty Bystrom | 66 | 1981-1985 | |
| 83 | Clayton Kershaw# | 66 | 1993-1999 | |
| 83 | Charlie Lea | 66 | 1980-1992 | |
| 86 | Danny Cox# | 64 | 1993-1998 | |
| 86 | Bill Drake | 64 | 1922-1990 | |
| 86 | Mike LaCoss | 64 | 1981-1992 | |
| 86 | Don Larsen# | 64 | 1990-1999 | |
| 90 | Lee Smith | 63 | 1980-1996 | |
| 91 | Yu Darvish# | 62 | 1994-1999 | |
| 92 | Bob Bruce | 61 | 1987-1996 | |
| 92 | Richard Dotson | 61 | 1981-1989 | |
| 92 | Felix Hernandez# | 61 | 1994-1999 | |
| 95 | Hal Newhouser# | 60 | 1994-1999 | |
| 96 | Steve Trout | 59 | 1980-1987 | |
| 97 | Storm Davis# | 58 | 1992-1999 | |
| 97 | Dennis Leonard | 58 | 1980-1989 | |
| 99 | Joe Gibbon | 57 | 1985-1995 | |
| 99 | Ray Kremer# | 57 | 1992-1999 |
