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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Fernando Valenzuela* | 224 | 1980-1996 | |
| 2 | Roger Clemens# | 209 | 1982-1999 | |
| 3 | Lefty Grove# | 154 | 1986-1999 | |
| 4 | Patrick Corbin | 114 | 1982-1997 | |
| 5 | Vinegar Bend Mizell# | 112 | 1988-1999 | |
| 6 | Jose DeLeon | 105 | 1984-1997 | |
| 7 | Steve Carlton | 101 | 1980-1987 | |
| 8 | Mario Soto | 92 | 1980-1987 | |
| 9 | Jack Morris | 90 | 1980-1992 | |
| 10 | Rick Rhoden | 89 | 1980-1990 | |
| 11 | Bruce Berenyi | 87 | 1981-1986 | |
| 12 | Scott Sanderson | 85 | 1980-1993 | |
| 13 | Kenta Maeda | 81 | 1986-1995 | |
| 14 | Happy Townsend# | 77 | 1984-1999 | |
| 15 | Bob Knepper | 75 | 1980-1989 | |
| 16 | Ben Sheets# | 73 | 1987-1999 | |
| 17 | Britt Burns | 72 | 1980-1996 | |
| 17 | Nolan Ryan | 72 | 1980-1988 | |
| 17 | Frank Tanana | 72 | 1980-1990 | |
| 20 | Ed Brandt# | 70 | 1986-1999 | |
| 21 | John Denny | 69 | 1980-1992 | |
| 22 | Masahiro Tanaka | 66 | 1984-1996 | |
| 23 | John Tudor | 65 | 1980-1994 | |
| 24 | Al Mamaux# | 63 | 1994-1999 | |
| 25 | Van Mungo# | 59 | 1987-1999 | |
| 26 | Floyd Bannister | 58 | 1980-1989 | |
| 27 | John Candelaria | 56 | 1980-1991 | |
| 28 | Dan Haren# | 53 | 1991-1999 | |
| 28 | Bruce Hurst | 53 | 1982-1994 | |
| 28 | Bob Ojeda | 53 | 1980-1993 | |
| 31 | Pascual Perez | 51 | 1981-1992 | |
| 31 | Mike Scott | 51 | 1980-1991 | |
| 31 | Jordan M Zimmermann# | 51 | 1989-1999 | |
| 34 | Dave Righetti# | 48 | 1991-1999 | |
| 34 | Jeff Weaver# | 48 | 1986-1999 | |
| 34 | Bill Wise# | 48 | 1990-1998 | |
| 37 | Bert Inks# | 47 | 1995-1999 | |
| 37 | Jerry Reuss | 47 | 1980-1987 | |
| 39 | Ron Guidry | 46 | 1980-1990 | |
| 39 | Christy Mathewson# | 46 | 1994-1999 | |
| 39 | Dave Stieb | 46 | 1981-1992 | |
| 39 | Rick Sutcliffe | 46 | 1980-1990 | |
| 39 | Bob Welch | 46 | 1980-1991 | |
| 39 | Carlos Zambrano# | 46 | 1988-1999 | |
| 45 | Don Robinson | 45 | 1980-1994 | |
| 46 | Marty Bystrom | 44 | 1981-1985 | |
| 46 | Mike Krukow | 44 | 1980-1988 | |
| 46 | Jack McDowell | 44 | 1983-1994 | |
| 49 | Kevin Appier# | 43 | 1988-1999 | |
| 49 | Ernie Broglio# | 43 | 1991-1999 | |
| 49 | Camilo Pascual# | 43 | 1984-1999 | |
| 52 | Yu Darvish# | 41 | 1994-1999 | |
| 52 | Al Orth# | 41 | 1991-1999 | |
| 54 | Charlie Leibrandt | 40 | 1981-1994 | |
| 55 | Len Barker | 38 | 1980-1985 | |
| 55 | J R Richard | 38 | 1980-1985 | |
| 57 | Mike Boddicker | 36 | 1981-1993 | |
| 57 | Jim Bunning# | 36 | 1998-1999 | |
| 57 | Dave LaPoint | 36 | 1981-1991 | |
| 60 | Frank Browning# | 34 | 1989-1999 | |
| 61 | Heinie Berger# | 33 | 1992-1999 | |
| 61 | Danny Darwin | 33 | 1980-1995 | |
| 61 | Willie Foster# | 33 | 1992-1999 | |
| 64 | Storm Davis# | 31 | 1992-1999 | |
| 65 | Mark W Davis | 29 | 1981-1994 | |
| 65 | Dennis Eckersley | 29 | 1980-1995 | |
| 65 | Matt Moore# | 29 | 1994-1999 | |
| 65 | Arlie Pond# | 29 | 1988-1999 | |
| 69 | Mike Flanagan | 28 | 1980-1988 | |
| 69 | LaMarr Hoyt | 28 | 1980-1991 | |
| 69 | Steve Trout | 28 | 1980-1987 | |
| 72 | Jim Abbott# | 27 | 1990-1997 | |
| 72 | Jim Beattie | 27 | 1980-1986 | |
| 72 | Jack Fisher# | 27 | 1996-1999 | |
| 72 | Scott Kazmir# | 27 | 1987-1999 | |
| 76 | Moose Haas | 26 | 1981-1989 | |
| 76 | Lee Richmond# | 26 | 0-0 | |
| 76 | Sonny Siebert# | 26 | 1997-1999 | |
| 79 | Tommy Bond# | 25 | 1994-1999 | |
| 80 | Oil Can Boyd# | 24 | 1987-1999 | |
| 80 | Bob Bruce | 24 | 1987-1996 | |
| 80 | Chris Devenski# | 24 | 1992-1999 | |
| 80 | J A Happ# | 24 | 1991-1999 | |
| 80 | Jay Howell | 24 | 1982-1994 | |
| 85 | Felix Hernandez# | 23 | 1994-1999 | |
| 85 | David Palmer | 23 | 1980-1991 | |
| 87 | Rich Gossage | 22 | 1980-1989 | |
| 87 | Al Holland | 22 | 1980-1989 | |
| 87 | Eddie Lopat | 22 | 1981-1985 | |
| 90 | Johnny Cueto# | 21 | 1992-1999 | |
| 90 | Paul Derringer# | 21 | 1997-1999 | |
| 90 | Steve Hamilton# | 21 | 1987-1999 | |
| 90 | Miles Mikolas# | 21 | 1993-1999 | |
| 94 | Charlie Lea | 20 | 1980-1992 | |
| 94 | Johnny Lush | 20 | 1987-1996 | |
| 94 | Scott McGregor | 20 | 1980-1982 | |
| 94 | Hal Newhouser# | 20 | 1994-1999 | |
| 94 | Pete Vuckovich | 20 | 1980-1984 | |
| 94 | Bill Walker# | 20 | 1992-1999 | |
| 100 | Michael Foltynewicz# | 19 | 1987-1999 |
